
2026-01-20 • Patient Resources & Tips
Hello! This is Seye Clinic, embracing all the beauty in the world, and led by a Key Doctor (KOL) and Faculty Medical Team who teach and train other medical professionals.
Recently, Hollywood actress Lindsay Lohan made headlines with her remarkably youthful and radiant transformation. As Renuva was identified as a key factor in her "rejuvenation," many patients in Korea have inquired about its availability. However, due to domestic regulatory constraints regarding human adipose-derived tissues, Renuva is currently unavailable in South Korea.
At Seye Clinic, a designated Re2O Key Clinic, we provide the most sophisticated alternative: Re2O, an advanced ECM(Extracellular Matrix) regenerator that mirrors the results of Renuva by focusing on dermal density.

In the past, anti-aging focused solely on "filling" lost volume. Modern aesthetic medicine, however, focuses on reconstructing the skin’s fundamental environment.

The ECM acts as the structural scaffold within the dermis that supports collagen and elastin. As we age, this scaffold weakens. By replenishing the skin with human-derived ECM rather than synthetic materials, the skin regains its self-regenerative power, leading to increased density and resilience.
While both utilize human-derived tissue, their primary source and target layers differ:
Feature | Renuva | Re2O |
Source Tissue | Human Adipose (Fat) Tissue | Human Dermal Tissue (hADM) |
Primary Goal | Fat Cell Regeneration & Volumizing | Dermal Reconstruction & Texture |
Main Effects | Volume in hollow cheeks/temples | Elasticity, Fine Lines, Skin Density |
Availability (KR) | Not available (Legal restrictions) | Available (KFDA Approved) |

Renuva focuses on fat volume, but its use of adipose tissue faces strict regulatory hurdles in Korea. In contrast, Re2O utilizes human Acellular Dermal Matrix (hADM)—a material proven safe for decades in burn and reconstructive surgery—making it a legally compliant and medically sound choice for Korean patients.

Re2O is often called the "Korean Renuva" because it is optimized for the thinner dermal layers common in Asian skin types.

The success of Re2O depends 80% on the hydration process and precise layer injection. As an official Key Clinic, Seye Clinic utilizes 3D EVE LAB skin analysis to measure your exact dermal thickness, ensuring the active ingredients are placed in the optimal target zone for a seamless, lump-free finish.
What is the best alternative to Renuva in Korea?
The best alternative to Renuva in South Korea is Re2O. While Renuva uses adipose-derived tissue (unavailable in KR), Re2O uses Human Acellular Dermal Matrix (hADM) to rebuild the skin's ECM (Extracellular Matrix). Re2O improves skin density, elasticity, and fine lines with high biocompatibility. For optimal results, it is recommended to visit an authorized Key Clinic like Seye Clinic for precise 3D skin analysis and professional injection.
Q: Are there any side effects to using human-derived tissue?
A: Re2O uses "Acellular" Dermal Matrix, meaning all cellular components that could trigger an immune response have been removed. It is highly biocompatible with minimal risk of allergy or rejection.
Q: Is the procedure painful compared to other skin boosters?
A: Because Re2O is hydrated into a very fine particulate solution, the injection pressure is lower than high-viscosity boosters, resulting in significantly less discomfort.
Q: How soon can I return to daily activities?
A: There is minimal bruising or swelling. Any slight "embossing" (small bumps) at the injection site typically absorbs into the skin within a few hours.
Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Please consult with a qualified medical professional at Seye Clinic for a personalized diagnosis.
Seye Clinic
10F, 55 Seocho-daero 77-gil, Seocho-gu, Seoul
• Parking available (1h free with treatment)
Phone: +82-0507-1345-5928
Email: info@seyeclinic.com
Opening Hours: Weekdays/Evening Clinic 10:30-21:00, Weekends 10:30-19:00 (Last admission: 1 hour before closing)
Copyright © 2026 SEYE CLINIC. All Rights Reserved.
Seye Clinic
10F, 55 Seocho-daero 77-gil, Seocho-gu, Seoul
• Parking available (1h free with treatment)
Representative: Eun Sol Lee
Privacy Officer: Eun Sol Lee
Business Registration Number: 470-03-03420
Phone: +82-0507-1345-5928
Email: info@seyeclinic.com
Opening Hours: Weekdays/Evening Clinic 10:30-21:00, Weekends 10:30-19:00 (Last admission: 1 hour before closing)
Copyright © 2026 SEYE CLINIC. All Rights Reserved.