
2026-01-13 • Patient Resources & Tips
Hello! This is Seye Clinic, embracing all the beauty in the world, and led by a Key Doctor (KOL) and Faculty Medical Team who teach and train other medical professionals.
"Skin booster results feel great at first, but why do they disappear so quickly?" This is a common frustration for patients after treatments like Rejuran or Juvelook. Often, this happens because these treatments "stimulate" cells without first repairing the skin’s depleted foundation. Today, we will discuss Re2O sessions, how this ECM booster reconstructs skin structure for long-lasting results, and how it compares to other top boosters.
Medical Disclaimer: This content is for informational purposes only. Please consult the specialists at Seye Clinic for a professional diagnosis and personalized treatment plan.
Re2O is an Extracellular Matrix (ECM) skin booster that utilizes micro-particulated Human Acellular Dermal Matrix (hADM). Skin aging begins when the ECM—the structural framework of the skin—breaks down. Unlike boosters that only provide hydration, Re2O directly replenishes actual dermal components like collagen, elastin, and hyaluronic acid to fundamentally rebuild the skin's environment.

While many boosters act as "stimulants" to wake up skin cells, Re2O acts as "raw material." By physically reinforcing the skin's foundation, the Re2O session effects remain stable as the particles are gradually integrated over 4–6 months. This creates a robust environment where the skin continues to self-regenerate, leading to long-term improvements in thickness and texture.

If you felt the longevity of other boosters was lacking, the difference lies in the mechanism of action.

Feature | Re2O (hADM) | Rejuran (PN) | Juvelook (PDLLA) |
Main Principle | Structural Reconstruction | Cell Regeneration Stimulant | Collagen Production Trigger |
Pain Level | Relatively Low | High (due to viscosity) | Moderate |
Key Benefit | Long-term Texture & Density | Oil-Water Balance & Glow | Natural Volume |
Longevity | Up to 12-18 months (after 3 sessions) | Short-term (approx. 3-6 months) | Mid-term (approx. 6-12 months) |
Re2O does not require frequent visits. The key is accumulating regenerative energy at the right intervals.
How long does Re2O last compared to Rejuran?
While Rejuran focuses on cellular repair with results lasting a few months, Re2O offers superior longevity (up to 18 months) by directly supplementing the Human Acellular Dermal Matrix (hADM). By rebuilding the skin's structural foundation (ECM), Re2O sessions provide more permanent improvements in skin density and texture compared to the temporary stimulation provided by PN or PDLLA boosters.
Q: Are there any side effects?
A: Because the hADM is processed to be "acellular" (removing cells that trigger immune responses), the risk of allergies or rejection is minimized.
Q: Who is the best candidate for Re2O?
A: It is ideal for aging skin with low self-regeneration, those who need rapid density improvement, or patients who fear the pain of traditional boosters.
Q: What is Seye Clinic’s "5cc Principle"?
A: We strictly follow a full 5cc dosage for every patient to ensure the highest density of ECM replenishment, rather than compromising on volume for lower costs.
"The World's First RE2O Key Clinic — SEYE Clinic"

Seye Clinic
10F, 55 Seocho-daero 77-gil, Seocho-gu, Seoul
• Parking available (1h free with treatment)
Phone: +82-0507-1345-5928
Email: info@seyeclinic.com
Opening Hours: Weekdays/Evening Clinic 10:30-21:00, Weekends 10:30-19:00 (Last admission: 1 hour before closing)
Copyright © 2026 SEYE CLINIC. All Rights Reserved.
Seye Clinic
10F, 55 Seocho-daero 77-gil, Seocho-gu, Seoul
• Parking available (1h free with treatment)
Representative: Eun Sol Lee
Privacy Officer: Eun Sol Lee
Business Registration Number: 470-03-03420
Phone: +82-0507-1345-5928
Email: info@seyeclinic.com
Opening Hours: Weekdays/Evening Clinic 10:30-21:00, Weekends 10:30-19:00 (Last admission: 1 hour before closing)
Copyright © 2026 SEYE CLINIC. All Rights Reserved.