
2025-12-02 • Patient Resources & Tips
Hello! This is Seye Clinic, embracing all the beauty in the world, and led by a Key Doctor (KOL) and Faculty Medical Team who teach and train other medical professionals.
Recently, many individuals have visited our clinic complaining of inner dryness and loss of elasticity due to the dry, transitional weather. Amid those seeking fundamental improvement in the skin's core density and structure—beyond what conventional skincare can achieve—there is growing interest in ECM (Extracellular Matrix) Skin Boosters.
Today, we will explain the core principle of ECM skin boosters and provide a detailed comparison with Rejuran to show you how you can safely choose Cellrdium while minimizing concerns about potential side effects.
Cellrdium is a skin booster that fundamentally improves the skin environment by replenishing the components of the Extracellular Matrix (ECM), which is the skin's core framework.

The reason concerns about Cellrdium side effects are comparatively low lies in the unique composition of 'human-derived Acellular Dermal Matrix (hADM)'. A comparison with one of the most well-known skin boosters, Rejuran (Rejuran Healer), highlights this distinction:
Category | Cellrdium | Rejuran |
Main Component | Human Acellular Dermal Matrix (hADM) | Polynucleotide (PN) |
Mechanism | Direct replenishment of skin components & environmental restoration | Indirect induction of collagen synthesis via cell signaling |
In addition to concerns about Cellrdium side effects, its level of pain is often compared to Rejuran. Specifically, many wonder about the difference from Rejuran HB Plus, which includes an anesthetic. The pain profiles are as follows:
Category | Cellrdium | Rejuran HB Plus |
Key Technology | 75µm Ultra-Fine Particle Design | Contains Local Anesthetic (Lidocaine) |
Pain Level | Pain minimized by ultra-fine particles | Average 53% reduction compared to Rejuran Healer |
Cellrdium is suitable for individuals with the following goals:
With ECM skin boosters, the result is more than half dependent on the skill and precision of the medical professional who accurately and uniformly injects the substance into the dermal layer.
We have reviewed the principles of ECM skin boosters and the features of Cellrdium to help you make a safe choice free from excessive worry about potential Cellrdium side effects. Most importantly, consult thoroughly with a specialist and receive an accurate diagnosis of your skin condition.
The content of this post adheres to the Medical Law and the Ministry of Health and Welfare's Medical Advertisement Guidelines.
Seye Clinic
10F, 55 Seocho-daero 77-gil, Seocho-gu, Seoul
• Parking available (1h free with treatment)
Phone: +82-0507-1345-5928
Email: info@seyeclinic.com
Opening Hours: Weekdays/Evening Clinic 10:30-21:00, Weekends 10:30-19:00 (Last admission: 1 hour before closing)
Copyright © 2025 SEYE CLINIC. All Rights Reserved.
Seye Clinic
10F, 55 Seocho-daero 77-gil, Seocho-gu, Seoul
• Parking available (1h free with treatment)
Representative: Eun Sol Lee
Privacy Officer: Eun Sol Lee
Business Registration Number: 470-03-03420
Phone: +82-0507-1345-5928
Email: info@seyeclinic.com
Opening Hours: Weekdays/Evening Clinic 10:30-21:00, Weekends 10:30-19:00 (Last admission: 1 hour before closing)
Copyright © 2025 SEYE CLINIC. All Rights Reserved.