
2026-01-05 β’ Patient Resources & Tips
Hello! This is Seye Clinic, embracing all the beauty in the world, and led by a Key Doctor (KOL) and Faculty Medical Team who teach and train other medical professionals.
Many patients seek skin elasticity improvements but hesitate due to the notorious pain associated with traditional skin boosters like Rejuran Healer. Today, we will provide a medical comparison of Re2O pain levels versus other treatments and explain how injection techniques can significantly reduce discomfort.
Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Please consult with a specialist at Seye Clinic for a personalized diagnosis.
Re2O is a next-generation skin booster designed to repair the skin's structural foundation rather than just providing temporary hydration.
The intensity of Re2O pain is determined by the tool and the target skin layer. Choosing the right method based on your sensitivity is crucial.

Feature | Hand Injection / Injector | Cannula Method |
Target Layer | Superficial Dermis (Shallow) | Subcutaneous / Deep Dermis |
Pain Level | Mild stinging sensation | Significantly lower / Comfortable |
Main Effect | Pores, fine lines, texture | Volume, contouring, lifting |
Downtime | Temporary embossing | Minimal bruising or swelling |
At Seye Clinic, we focus on two technical details to ensure a painless experience:

Does Re2O hurt?
Compared to Rejuran, Re2O is generally reported to be less painful, especially when administered via the cannula method. While Rejuran's high viscosity and shallow injection often cause a stinging sensation, Re2Oβs pain can be effectively managed through professional mixing protocols and deep-layer targeting, offering a more comfortable experience with long-term ECM reconstruction benefits.
Q: How does Re2O pain compare to Rejuran?
A: Rejuran has high viscosity and is injected into the shallow dermis, often causing more discomfort. Re2O, when combined with a cannula and proper mixing, provides a much smoother and more comfortable session.
Q: Can I wear makeup immediately after the procedure?
A: Yes. If the cannula method is used, there are almost no visible marks. Hand injections may leave tiny needle marks that usually disappear within 24 hours.
Q: How long do the results last?
A: Because it improves the fundamental skin environment (ECM), results typically last over 6 months. Cumulative benefits are observed with repeated treatments.
Seye Clinic
10F, 55 Seocho-daero 77-gil, Seocho-gu, Seoul
β’ Parking available (1h free with treatment)
Phone: +82-0507-1345-5928
Email: info@seyeclinic.com
Opening Hours: Weekdays/Evening Clinic 10:30-21:00, Weekends 10:30-19:00 (Last admission: 1 hour before closing)
Copyright Β© 2026 SEYE CLINIC. All Rights Reserved.
Seye Clinic
10F, 55 Seocho-daero 77-gil, Seocho-gu, Seoul
β’ Parking available (1h free with treatment)
Representative: Eun Sol Lee
Privacy Officer: Eun Sol Lee
Business Registration Number: 470-03-03420
Phone: +82-0507-1345-5928
Email: info@seyeclinic.com
Opening Hours: Weekdays/Evening Clinic 10:30-21:00, Weekends 10:30-19:00 (Last admission: 1 hour before closing)
Copyright Β© 2026 SEYE CLINIC. All Rights Reserved.