
2025-12-16 • Patient Resources & Tips
Hello! This is Seye Clinic, embracing all the beauty in the world, and led by a Key Doctor (KOL) and Faculty Medical Team who teach and train other medical professionals.
As the weather becomes drier, more people are struggling with fine lines and enlarged pores. To fundamentally improve the skin environment, many are turning to skin boosters. Specifically, we receive many inquiries regarding the RE2O vs Rejuran comparison.
Today, we will clarify the differences in their principles, ingredients, pain levels, and how quickly you can expect to see results.
While both treatments involve injecting active ingredients into the dermal layer, their core materials and mechanisms differ significantly.
Category | RE2O (ECM Skin Booster) | Rejuran (PN Skin Booster) |
Key Ingredient | Human-derived ECM (Collagen, etc.) | Salmon-derived PN (DNA fragments) |
Mechanism | Directly replenishes lost structural components | Sends signals to cells to induce collagen |
Primary Effect | Pore reduction, dermal thickening, elasticity | Inner hydration, oil-water balance |
The core of the RE2O vs Rejuran comparison is that RE2O directly fills the "scaffolding" of the skin, whereas Rejuran stimulates the "regenerative activity" of the cells.
Pain is a major factor when choosing a skin booster. This is where RE2O holds a significant advantage.

Rather than one being "better," the choice should depend on your specific skin concerns and aging progress.
No matter how premium the product is, the results depend on "where and how" it is injected. Skin boosters must be distributed accurately and evenly within the dermis to achieve the desired change.
We hope this RE2O vs Rejuran comparison helps you make an informed choice for your skin's health.
Seye Clinic
10F, 55 Seocho-daero 77-gil, Seocho-gu, Seoul
• Parking available (1h free with treatment)
Phone: +82-0507-1345-5928
Email: info@seyeclinic.com
Opening Hours: Weekdays/Evening Clinic 10:30-21:00, Weekends 10:30-19:00 (Last admission: 1 hour before closing)
Copyright © 2025 SEYE CLINIC. All Rights Reserved.
Seye Clinic
10F, 55 Seocho-daero 77-gil, Seocho-gu, Seoul
• Parking available (1h free with treatment)
Representative: Eun Sol Lee
Privacy Officer: Eun Sol Lee
Business Registration Number: 470-03-03420
Phone: +82-0507-1345-5928
Email: info@seyeclinic.com
Opening Hours: Weekdays/Evening Clinic 10:30-21:00, Weekends 10:30-19:00 (Last admission: 1 hour before closing)
Copyright © 2025 SEYE CLINIC. All Rights Reserved.