Is Rejuran Too Painful? Discover the Painless Rejuran HB Plus

Hello! This is Seye Clinic, embracing all the beauty in the world, and led by a Key Doctor (KOL) and Faculty Medical Team who teach and train other medical professionals.

Many patients come to us fascinated by skin regeneration but hesitant because of Rejuran's "notorious" reputation for pain. To address it, Rejuran's maker PharmaResearch released Rejuran HB Plus, which adds lidocaine to reduce discomfort — though it comes with a trade-off. That's why Seye Clinic developed, through its own research, a Pain-Free Rejuran that keeps the full active dose while still minimizing pain. In this post we'll compare the classic Rejuran Healer with Rejuran HB Plus — and explain our own approach — with a link to our full Pain-Free Rejuran guide just below.

👉🏻 Read the full guide: Seye's Pain-Free Rejuran →

1. The Science of Rejuran: Salmon DNA Regeneration

Rejuran is a premium skin booster that injects Polynucleotides (PN), extracted from salmon DNA, directly into the dermal layer.

• How it Works: PN is highly biocompatible with human DNA, minimizing the risk of rejection.
• Benefits: It triggers the skin’s self-regeneration, promotes collagen synthesis, and restores damaged skin structures from the inside out.

2. How Seye Makes Rejuran Pain-Free

How much a treatment stings comes down to the formulation. To ease it, PharmaResearch released Rejuran HB Plus, which adds Lidocaine (a local anesthetic) and Hyaluronic Acid (HA) to the classic Rejuran Healer.

There's a trade-off, though: in the same 2cc, the Lidocaine and HA take up space, so the actual Rejuran active dose is reduced by that amount. Seye's Pain-Free Rejuran was built to avoid exactly that — our own recipe and protocol keep the full active dose while minimizing pain through thorough numbing, a precision ultra-fine injector, and an aftercare protocol we developed ourselves.

This was not an easy road. Pain is felt differently by every person, and controlling all the factors behind it — while maximizing the results — is genuinely difficult. To complete a recipe that is low-pain in practice and not just in name, Seye Clinic ran many experiments and studies, refining the entire process end to end: not just how the solution is mixed, but everything from the injection protocol to the aftercare protocol.

3. Which One Should You Choose?

Your choice should depend on your pain tolerance and specific skin goals.

• Choose Rejuran Healer if: You want the most concentrated focus on skin structural repair and elasticity, and you have a moderate pain tolerance.
• Choose Rejuran HB Plus if: You are sensitive to pain and want to combine skin regeneration with a "water-glow" hydrating effect.

4. Seye Clinic’s Know-How for a Comfortable Experience

Beyond the formulation itself, the injection technique is just as important to a truly comfortable result. This is the part we refined through our own experience, and it's where Seye Clinic goes the extra mile:

• Precision Planning: We customize the treatment plan based on your skin thickness and specific concerns.
• Advanced Pain Management: In addition to the lidocaine in the product, we provide ample numbing cream time, specialized cooling care, and delicate injection techniques to minimize downtime and discomfort.
• Guaranteed Authenticity: We believe in transparency. We verify the genuine product activation sticker with you directly before starting the procedure.

5. Post-Treatment Care: What to Expect

Whether you choose the classic or the pain-free version, proper aftercare ensures the best results:

• Embossing Effect: Small bumps (embossing) at the injection sites are a natural sign that the active ingredients were delivered correctly. These usually subside within 1 to 3 days.
• Daily Life: Recovery is very fast, allowing you to return to your normal routine almost immediately.
• Initial Precautions: Avoid excessive drinking, saunas, and strenuous exercise for about one week following the treatment.

If pain has been your only barrier to healthier skin, Seye's Pain-Free Rejuran is a comfortable way forward. The most important step is finding the right solution through a proper diagnosis — and you can read the complete protocol in our dedicated Pain-Free Rejuran guide, linked in this post.