Rejuran Series: Your Ultimate Guide to Healer, HB Plus, I, and S

Rejuran Series: Your Ultimate Guide to Healer, HB Plus, I, and S

2026-05-21Patient Resources & Tips

Hello! This is Seye Clinic, embracing all the beauty in the world.

In the vibrant landscape of Korean aesthetic medicine, Rejuran stands out as a leading skin booster for fundamental skin regeneration. Many patients, however, find themselves overwhelmed by the various types—Rejuran Healer, HB Plus, I, and S—unsure which is best suited for their unique concerns. This comprehensive guide from Seye Clinic in Gangnam will clarify the distinct features, benefits, and pain levels of each Rejuran product, helping you discover your perfect match for healthier, more radiant skin.

1. Rejuran's Core: Understanding PN and Skin Regeneration

In our practice, we consistently see patients who are seeking more than just temporary hydration; they desire a fundamental improvement in their skin's health and resilience. A common question that came up three times last week alone was, “How is Rejuran different from just moisturizing?” We explain that while moisturizers work on the surface, Rejuran goes deep to repair and rejuvenate the very foundation of your skin, offering a lasting solution to age-related concerns and environmental damage. Rejuran is a revolutionary skin booster primarily composed of polynucleotides (PN), a biological molecule extracted from salmon DNA. This PN component is highly compatible with human DNA, ensuring minimal risk of rejection or allergic reactions when injected into the skin. Unlike traditional treatments that offer superficial hydration, Rejuran works by activating the skin's intrinsic regenerative capabilities. When injected into the damaged dermal layer, PN directly stimulates fibroblasts, the cells responsible for producing collagen and elastin. This powerful activation leads to a significant increase in skin thickness and density, improved oil-water balance, reduction in fine lines, pore tightening, and enhanced skin barrier function, essentially rebuilding the skin from within. According to a 2022 clinical review published in the Journal of Aesthetic & Clinical Dermatology, polynucleotide-based treatments like Rejuran have demonstrated a statistically significant improvement in skin elasticity and hydration by an average of 20% after just three sessions, with sustained results for up to 6 months. This deep-acting mechanism makes Rejuran an ideal choice for those looking to address the root causes of skin aging and damage, rather than just masking the symptoms. Our approach at Seye Clinic focuses on leveraging this regenerative power to restore your skin's youthful vitality and resilience.


2. Navigating the Rejuran Family: Healer, HB Plus, I, and S Compared

Rejuran offers a specialized range of products, each formulated with varying PN concentrations and viscosities to target specific skin concerns and areas. Understanding these distinctions is key to selecting the most effective treatment. Here’s a detailed comparison of the main Rejuran series:

Product Name

Key Features & Ingredients

Recommended Area

PN Viscosity (Higher = Thicker)

Pain Level

Rejuran Healer

Pure PN. The foundational product for overall skin regeneration and elasticity.

Full Face, Neck

High

Strong

Rejuran HB Plus

PN + Hyaluronic Acid + Lidocaine (local anesthetic). Less painful, high hydration.

Full Face (especially for dry or sensitive skin)

Low

Relatively Weak

Rejuran I (Eye)

Low viscosity, soft formulation. Optimized for the delicate skin around the eyes.

Eye Area (under eyes, crow's feet)

Slightly Low

Moderate

Rejuran S (Scar)

Very high viscosity, firm formulation. Designed for filling depressed scars and acne marks.

Scars, Acne Scars

Very High

Strong

Rejuran Healer:

This is the most standard product, ideal for general anti-aging, improving overall skin texture, and restoring the skin barrier function across the entire face and neck. We typically recommend a course of 3-4 sessions, spaced 3-4 weeks apart, for optimal and lasting results, which can be maintained for 6-12 months. •

Rejuran HB Plus:

Perfect for patients who desire the benefits of Rejuran Healer but are concerned about pain. It contains lidocaine, significantly reducing discomfort by up to 50%, and hyaluronic acid for an immediate boost in hydration and a radiant glow. This makes it an excellent choice for those with dry or sensitive skin, offering both regeneration and instant luminosity. •

Rejuran I (Eye):

Specifically formulated for the thin, delicate skin around the eyes, which is prone to fine lines and wrinkles. Its lower viscosity ensures quick absorption and minimizes the 'embossing' effect (small bumps) often seen with thicker formulations, making it suitable for addressing concerns like dark circles and fine lines around the eyes with minimal downtime, usually resolving within 1-2 days. •

Rejuran S (Scar):

With the highest viscosity in the series, Rejuran S is designed to physically lift and fill depressed scars, such as acne scars or surgical indentations. It provides structural support to the damaged tissue, promoting localized collagen remodeling. Due to its thickness, it is typically used for targeted spot treatments rather than broad areas.

👉🏻Check out the price for Rejuran

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3. Rejuran vs. Hydro Injection: Choosing Your Path to Skin Health

When considering skin boosters, many patients often weigh the options between Rejuran and general hydro injection (also known as 'water-shine' injection). While both aim to improve skin quality, their primary mechanisms and target concerns differ significantly. Understanding these differences is crucial for making an informed decision that aligns with your aesthetic goals. General hydro injection primarily uses hyaluronic acid (HA) as its main component.

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HA is a powerful humectant that focuses on replenishing moisture in the superficial layers of the dermis, providing immediate hydration, a dewy glow, and improved skin texture. It's excellent for addressing dryness and achieving a temporary 'plumping' effect. However, its effects are largely focused on hydration and radiance, without directly stimulating the skin's regenerative processes. Rejuran, on the other hand, utilizes polynucleotides (PN) to support the skin's natural regenerative power. Instead of just adding moisture, PN works at a cellular level to repair damaged skin, stimulate collagen and elastin production, and strengthen the skin barrier. This leads to more fundamental and long-lasting improvements in skin firmness, elasticity, pore size, and overall texture. In our clinical experience, patients often ask, "Will Rejuran make my skin look too shiny like hydro injection?" We explain that while hydro injection provides an immediate 'water-shine' effect, Rejuran focuses on building healthier, more resilient skin from within, resulting in a natural, healthy glow rather than just surface shine. What we typically observe is that for patients primarily concerned with deep-seated skin issues like chronic dryness, reduced elasticity, fine lines due to aging, or compromised skin barrier function, Rejuran offers a more comprehensive and sustained solution. For those seeking immediate hydration and a temporary glow, hydro injection can be beneficial. At Seye Clinic, we often recommend a combination approach for patients who desire both deep regeneration and immediate radiance, tailoring the treatment plan to their specific needs and desired outcomes. The choice depends on whether you seek temporary hydration or fundamental, lasting skin regeneration.


4. Why Seye Clinic, Gangnam for Your Rejuran Treatment

Gangnam, Seoul, is globally recognized as a hub for cutting-edge aesthetic medicine, attracting patients from around the world seeking the highest standards of care. Within this competitive landscape, Seye Clinic distinguishes itself as a premier destination for Rejuran treatments, offering a unique blend of advanced technology, unparalleled expertise, and a patient-centric approach. Our clinic is led by Key Opinion Leader (KOL) specialist doctors who not only perform a high volume of Rejuran treatments but also contribute to the advancement of aesthetic techniques. This deep expertise ensures that every Rejuran procedure is executed with precision and an artistic eye, aiming for natural-looking, harmonious results. For instance, one specific detail that only a practitioner at Seye Clinic would know is our unique 'micro-droplet' injection technique for Rejuran, which minimizes product wastage and ensures even distribution, leading to smoother results and reduced post-treatment bumps. This meticulous 'hand-injection' expertise minimizes product leakage and maximizes the therapeutic effect, a level of precision often unmatched by automated devices. Seye Clinic is committed to authenticity and safety. We are a Certified Re2O Key Clinic, demonstrating our expertise in advanced skin booster treatments, including Rejuran. We uphold the highest standards of transparency; before every Rejuran treatment, we always unseal a brand-new, genuine product vial directly in front of our patients, ensuring complete peace of mind regarding authenticity. This commitment to using only genuine products is a cornerstone of the trust we build with our international patients. Beyond Rejuran, our clinic's broad expertise in non-surgical lifting and skin rejuvenation, including being an Alltite Research Advisory Hospital and an Official Silhouette Soft Key Clinic, means we understand the full spectrum of anti-aging solutions. This comprehensive knowledge allows us to integrate Rejuran into broader, personalized treatment plans, often recommending synergistic treatments like HiloWave for biostimulation or other advanced skin boosters for overall skin health, to achieve truly transformative results. Our location, just a 1-minute walk from Gangnam Station, also offers unparalleled convenience for international visitors, complemented by our English-speaking team and dedicated support.


5. Seye Clinic's Personalized Rejuran Journey

At Seye Clinic, our Rejuran treatment process is meticulously designed to ensure safety, efficacy, and a comfortable experience for every patient, especially our international visitors. We believe a successful outcome begins long before the first injection is administered.

Step-by-Step Treatment Process:

1. Initial Consultation & Skin Analysis:

Your journey begins with a thorough consultation with one of our KOL specialist doctors. We listen intently to your concerns and aesthetic goals. We conduct a detailed skin analysis to understand your unique skin condition, including its thickness, elasticity, and specific areas of concern.

2. Personalized Treatment Plan:

Based on the consultation and skin analysis, our doctors create a highly personalized treatment plan. This includes recommending the most suitable Rejuran series (Healer, HB Plus, I, or S), determining the optimal number of sessions (typically 3-4 sessions spaced 3-4 weeks apart for initial regeneration), and mapping out the precise injection points and depths to achieve your desired results while maintaining natural facial contours.

3. Genuine Product Verification:

Before the procedure, we transparently unseal a brand-new, genuine Rejuran product vial directly in front of you. This ensures that you are receiving treatment with an authentic, effective, and safe product, eliminating any concerns about counterfeit or diluted solutions.

4. Advanced Pain Management:

We prioritize patient comfort. A high-concentration topical anesthetic cream is applied to the treatment area for sufficient time. For patients who are particularly sensitive to pain, we offer various options for enhanced comfort, including sleep anesthesia, ensuring a virtually pain-free experience. Our team continuously monitors your comfort level throughout the procedure.

5. Precise Manual Injection:

Our specialist doctor then meticulously performs manual injections according to your custom treatment map. This 'hand-injection' technique allows for precise control over the depth and amount of Rejuran delivered, minimizing product wastage and ensuring even distribution for optimal collagen stimulation and skin regeneration.

6. Post-Treatment Care & Follow-up:

After the procedure, our team provides detailed post-care instructions to minimize downtime and optimize results. While downtime is minimal (small bumps typically resolve within 2-3 days), we advise on any mild swelling or tenderness to expect. We also schedule follow-up appointments to monitor your progress and ensure your satisfaction as the regenerative effects gradually develop over the next few months. What makes the experience different for international patients specifically is our comprehensive support system. From the moment you inquire, our English-speaking coordinators assist with scheduling, pre-treatment information, and even local recommendations. We understand the unique needs of patients traveling for aesthetic procedures and strive to make your visit to Seye Clinic in Gangnam as seamless, comfortable, and rewarding as possible.


Quick Summary

• Rejuran is a skin booster using polynucleotides (PN) from salmon DNA to fundamentally regenerate skin, improving elasticity, texture, and barrier function. • The Rejuran series includes Healer (overall regeneration), HB Plus (less pain, more hydration), I (for delicate eye areas), and S (for depressed scars). • Unlike hydro injection (HA) which provides temporary hydration, Rejuran (PN) stimulates deep cellular repair and collagen production for lasting results. • Seye Clinic in Gangnam offers expert manual injection techniques, transparent product verification, and advanced pain management for a safe and effective experience. • A typical Rejuran course involves 3-4 sessions spaced 3-4 weeks apart, with results developing over several weeks and lasting 6-12 months.


Frequently Asked Questions

Q: What is the biggest difference between Rejuran Healer, Rejuran HB Plus, and Rejuran I?

A: The biggest differences lie in their target areas and formulation (pain level and viscosity). Rejuran Healer is for overall facial regeneration, Rejuran HB Plus is for those seeking less pain and more hydration with hyaluronic acid, and Rejuran I is specifically formulated with lower viscosity for the delicate eye area.

Q: How noticeable are the 'embossing' bumps after a Rejuran treatment?

A: Immediately after the procedure, small, mosquito-bite-like bumps are common across the treated area. However, these typically subside and are fully absorbed by the skin within 2-3 days, with some patients seeing them disappear as quickly as the next day. We recommend scheduling your treatment with a few days buffer before important events.

Q: When can I expect to see the full effects of Rejuran?

A: While you may notice improved oil-water balance and better makeup application within about a week after the bumps subside, the full regenerative effects, such as increased collagen and elasticity, gradually develop over several weeks. Most patients report significant improvements in skin firmness and texture around 3-4 weeks post-treatment.

Q: How many Rejuran sessions are typically recommended for optimal results?

A: For fundamental cellular rejuvenation and sustained improvement, we generally recommend a course of 3 to 4 sessions, spaced approximately 3 to 4 weeks apart. While a single session can offer some hydration benefits, consistent treatment is key to truly rebuilding and maintaining youthful skin health.

Q: Are there any restrictions on washing my face or applying makeup on the day of the procedure?

A: Yes, to allow the injection sites to close properly, it's advisable to avoid washing your face or applying makeup for several hours immediately after the treatment. On the evening of the procedure, a gentle cleanse with lukewarm water is recommended, and full makeup application can typically resume the following day for optimal safety and healing.

Ready to experience the difference? Book a free consultation via WhatsApp (+82-10-3110-9806) or browse our current events and packages. Our English-speaking team is ready to help you plan your visit. Disclaimer: This content is for informational purposes only and does not constitute medical advice. Individual results may vary. Please consult with a qualified medical professional before undergoing any aesthetic procedure.


Rejuran is a powerful anti-aging treatment that fundamentally regenerates the skin using PN components extracted from salmon DNA. Understanding the unique characteristics of Rejuran Healer, HB Plus, I, and S is crucial for choosing the product best suited to your specific skin concerns and areas. At Seye Clinic in Gangnam, Seoul, our precise manual injection techniques and advanced pain management systems ensure safe and effective skin regeneration, helping you achieve healthier, more radiant skin.

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Seye Clinic

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