
2026-09-16 • Patient Resources & Tips
Hello! This is Seye Clinic, embracing all the beauty in the world.
In our practice, we consistently see patients who hesitate to undergo skin barrier strengthening treatments like Rejuran due to the intense pain they've experienced previously. At Seye Clinic, we've developed a specialized Pain-Free Rejuran solution, utilizing advanced injector techniques to significantly reduce discomfort, bruising, and swelling, ensuring a comfortable and effective skin booster experience for glowing, healthy skin.
In our clinical experience, a common concern among patients considering skin booster treatments is the anticipated discomfort. Rejuran, a highly effective skin booster derived from salmon polynucleotides (PN), plays a crucial role in strengthening damaged skin barriers and promoting regeneration.
However, the unique properties of the Rejuran solution itself contribute to the sensation of pain. The polynucleotide (PN) molecules are relatively large and possess a higher viscosity compared to other injectables. When this viscous solution is directly injected into the thin and sensitive dermal layer of the skin, it creates a feeling of pressure and dull ache. This physical stimulation on the delicate facial surface inevitably leads to significant discomfort during the procedure. Many patients describe it as a stinging or burning sensation, which can be a major deterrent, even for those who understand the profound benefits of Rejuran for skin health. Understanding this inherent characteristic of the treatment is the first step in developing strategies to mitigate the pain, making the rejuvenating effects of Rejuran accessible to more individuals.
At Seye Clinic, we are committed to transforming the Rejuran experience from a dreaded procedure into a comfortable and even pleasant one. Our specialized Pain-Free Rejuran protocol focuses on minimizing physical irritation at every stage, from anesthesia to the injection technique and the formulation itself.
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• Optimal Numbing Process: Unlike conventional methods that might rush the numbing phase, we prioritize sufficient topical anesthesia. A generous layer of high-potency anesthetic cream is applied thickly and broadly across the treatment area. We then allow an ample waiting period, typically 30-40 minutes, for the active ingredients to fully penetrate the skin, ensuring a profound reduction in surface sensation before the procedure begins. This meticulous approach significantly diminishes initial discomfort.
• Custom-Formulated Solution: To further alleviate the inherent resistance and pressure associated with injecting the pure Rejuran solution, we utilize a custom-blended solution. This proprietary mix combines Rejuran with carefully selected ingredients that enhance hydration and provide additional sensory relief. This synergistic formulation not only reduces the "push" sensation during injection but also boosts the overall moisturizing effect, contributing to a more comfortable experience and superior skin hydration.
These systematic steps in our Pain-Free Rejuran treatment are designed not only to alleviate patient anxiety regarding pain but also to enhance the overall hydration and health of the dermal layer, leading to more radiant and resilient skin.

Beyond our specialized formulation, the method of delivery is paramount to a truly pain-free and effective Rejuran treatment. While manual injections by a practitioner can be precise, they often involve varying pressure and depth, which can lead to increased bruising, swelling, and discomfort. At Seye Clinic, we leverage precision injector devices equipped with ultra-fine needles for our Pain-Free Rejuran procedures.
This advanced technology offers several key advantages:
• Consistent Depth and Uniform Pressure: The injector device ensures that the active ingredients are delivered into the skin at a consistent depth and with uniform pressure. This eliminates the variability of manual injections, significantly reducing the risk of excessive pressure that can cause bruising or swelling.
• Ultra-Fine Needles: Our injectors are fitted with specially designed, extremely thin needles, far finer than standard needles. This dramatically minimizes physical trauma to the skin's surface, resulting in less irritation and fewer visible needle marks post-treatment. Patients often report that the sensation is barely noticeable, akin to a light prick.
• Precise Targeting: The controlled delivery system allows for highly precise targeting of the treatment areas, ensuring that the Rejuran is distributed evenly across the dermis where it can exert its maximum regenerative effects. This precision is a core technological principle behind our Pain-Free Rejuran, leading to more predictable and satisfying outcomes with minimal downtime.
In our clinical experience, patients who have previously undergone manual Rejuran injections are often astonished by the difference in comfort and the rapid recovery time when treated with our precision injector system.

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A common question patients have after a Rejuran treatment is about the post-procedure appearance and recovery time. With Seye Clinic's Pain-Free Rejuran, which utilizes ultra-fine injectors, the physical trauma to the epidermis is significantly reduced, leading to a much faster recovery.
• Embossing and Redness: Immediately after the procedure, you might notice small, raised bumps (embossing) and some mild redness at the injection sites. These are natural and temporary responses. Thanks to our ultra-fine injector technique, these marks typically subside rapidly, usually within 1 to 2 days. In some cases, they may be barely visible after just a few hours.
• Return to Daily Life: You can typically resume light makeup and facial cleansing from the day after the procedure. We advise against vigorous rubbing or harsh skincare products for the first few days.
•Aftercare Recommendations: The period immediately following Rejuran treatment is crucial for the skin's regeneration process. We strongly recommend applying regenerative creams and rich moisturizers more generously than usual. Keeping the skin well-hydrated and protected supports the healing process and optimizes the results of the Rejuran. Avoid direct sun exposure and use a broad-spectrum sunscreen diligently.
In our clinical experience, patients appreciate the minimal downtime associated with our Pain-Free Rejuran, allowing them to quickly return to their daily routines with refreshed and revitalized skin.
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At Seye Clinic, located conveniently in Gangnam, Seoul, we understand that even the most advanced regenerative treatment like Rejuran requires a highly personalized approach. The effectiveness of any skin booster hinges on accurately assessing each patient's unique skin thickness, anatomical structure, and specific concerns.
Our commitment to precision begins with a thorough diagnostic process. We utilize the EVELAB 3D skin diagnostic system to objectively and meticulously analyze the condition of your dermal layer. This advanced technology provides a comprehensive understanding of your skin's needs, allowing us to identify the exact areas and depths requiring treatment. Based on this objective data, our KOL (Key Opinion Leader) specialist doctors formulate a customized treatment plan tailored precisely to your skin's unique profile.
Furthermore, transparency and trust are cornerstones of our practice. We conduct all procedures in private, individual treatment rooms, ensuring your comfort and privacy.
Before every Rejuran injection, we adhere strictly to the principle of using the correct dosage and verify the authenticity of the product through digital NFC tag authentication.
This process assures you that you are receiving genuine Rejuran, administered with the highest standards of care.
Choosing Seye Clinic for your Rejuran treatment means opting for a clinic that combines cutting-edge technology, specialized expertise, and a deep commitment to patient comfort and safety. Our location in the heart of Gangnam, just a 1-minute walk from Gangnam Station, makes us easily accessible for both local and international patients seeking premium aesthetic dermatology.
At Seye Clinic, your journey to revitalized skin with Pain-Free Rejuran is meticulously planned and executed to ensure both comfort and optimal results.
This comprehensive approach, combining advanced diagnostics, personalized care, and our unique Pain-Free Rejuran technique, sets Seye Clinic apart. We are dedicated to making your aesthetic journey as comfortable and rewarding as possible.
• Pain-Free Rejuran: at Seye Clinic significantly reduces discomfort, bruising, and swelling for skin barrier strengthening.
• Our unique protocol includes optimal topical anesthesia and a custom-blended Rejuran solution for enhanced comfort and hydration.
• Precision injector devices with ultra-fine needles ensure consistent depth, uniform pressure, and minimal downtime (typically 1-2 days).
• EVELAB 3D skin diagnostics and personalized treatment plans by KOL specialist doctors ensure tailored and effective results.
• Seye Clinic in Gangnam offers transparent procedures with digital NFC tag authentication for genuine Rejuran.
Q: What makes Seye Clinic's Rejuran "Pain-Free"?
A: Seye Clinic's Pain-Free Rejuran utilizes a multi-faceted approach including optimal topical anesthesia, a custom-blended Rejuran solution to reduce viscosity, and precision injector devices with ultra-fine needles. This combination significantly minimizes the discomfort typically associated with Rejuran injections, making the experience much more comfortable for patients.
Q: How long does the downtime typically last after a Pain-Free Rejuran treatment?
A: Thanks to the precision injector and ultra-fine needles used in our Pain-Free Rejuran, the downtime is significantly reduced. Any temporary embossing or redness usually subsides within 1 to 2 days. Most patients can resume light makeup and daily activities from the day after the procedure, with minimal visible signs of treatment.
Q: Can Pain-Free Rejuran help with specific skin concerns like acne scars or fine lines?
A: Yes, Rejuran is highly effective for a range of skin concerns. Its primary function is to strengthen the skin barrier, promote collagen production, and improve overall skin regeneration. This leads to visible improvements in fine lines, skin texture, pore size, and even mild acne scars. Our personalized approach ensures the treatment targets your specific concerns for optimal results.
Q: How many sessions of Pain-Free Rejuran are recommended for optimal results?
A: For optimal and lasting results, a course of 3 to 4 sessions, spaced 2 to 3 weeks apart, is generally recommended. Following the initial course, maintenance treatments every 3 to 6 months can help sustain the benefits and keep your skin healthy and radiant. Our doctor will provide a tailored recommendation during your consultation.
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Ready to experience the difference? Book a free consultation via WhatsApp (+82-10-3110-9806) or browse our current events and packages. Our English-speaking team is ready to help you plan your visit.
*This content is for informational purposes only and does not constitute medical advice. Individual results may vary. Please consult a qualified medical professional before undergoing any aesthetic procedure.
Seye Clinic
10F, 55 Seocho-daero 77-gil, Seocho-gu, Seoul
• Parking available (1h free with treatment)
Phone: +82-507-1345-5928
Email: info@seyeclinic.com
Opening Hours: Weekdays/Evening Clinic 10:30-21:00 (reservation cutoff 19:00), Weekends/Public Holidays 10:30-19:00 (reservation cutoff 17:00)
Copyright © 2026 SEYE CLINIC. All Rights Reserved.
Seye Clinic
10F, 55 Seocho-daero 77-gil, Seocho-gu, Seoul
• Parking available (1h free with treatment)
Representative: Eun Sol Lee
Privacy Officer: Eun Sol Lee
Business Registration Number: 470-03-03420
Phone: +82-507-1345-5928
Email: info@seyeclinic.com
Opening Hours: Weekdays/Evening Clinic 10:30-21:00 (reservation cutoff 19:00), Weekends/Public Holidays 10:30-19:00 (reservation cutoff 17:00)
Copyright © 2026 SEYE CLINIC. All Rights Reserved.